Level: guides differ slightly here — Vandal, EliteGuías and most wikis say 34, while CD Projekt Red's own announcement named 35. Either way, treat it as the last DLC to start.
Trigger: The quest "Envoys, Wineboys" — knights who seek you out — added once you have finished "A Poet Under Pressure"; "The Beast of Toussaint" is the quest that follows.
Unlocks: The huge region of Toussaint, mutations, Grandmaster gear, and your own home — Corvo Bianco.
1. The Beast of Beauclair
Duchess Anna Henrietta summons you to Toussaint to stop a series of grisly murders. The trail leads to a higher vampire — and to a reunion with an old friend, Regis. Investigate the crime scenes with Witcher Senses to unmask the killer's pattern.
2. Dettlaff & Syanna
The "Beast" is Dettlaff, a higher vampire being blackmailed. The woman he's protecting — and the one pulling the strings — is Syanna, the Duchess's estranged sister. To reach her you journey into the storybook Land of a Thousand Fables, one of the game's most enchanting sequences.
3. The Final Choice
Blood and Wine actually has three distinct endings, not two. Miss the ribbon in the Land of a Thousand Fables and Syanna dies to Dettlaff — the middle outcome. Antagonize her instead (harsh dialogue in the tower, or meeting the Unseen Elder before her storyline finishes) and both sisters die — the worst one. For "everyone lives," you need the ribbon, to look into Syanna's reasons with Regis in "Pomp and Strange Circumstance", and a full run of sympathetic dialogue: steer every conversation with Syanna, and Geralt's own words at her sentencing, toward mercy and reconciliation with Anna Henrietta. Then face Dettlaff in a brutal two-phase fight (Yrden circle + crossbow to ground his misty form).
4. Corvo Bianco & Rewards
Toussaint gives Geralt the retirement he deserves: the vineyard Corvo Bianco, which you can furnish and upgrade — racks for your gear, an alchemy lab, a garden for growing your own ingredients, bonuses for resting. Buying every available upgrade runs to roughly 14,000 crowns in total, across the "No Place Like Home" quest, so pace it rather than trying to pay it all at once.
You also unlock Mutations through the side quest "Turn and Face the Strange" and Professor Moreau's laboratory: thirteen of them across four trees (one, Strengthened Synapses, runs passively, which is why some guides count twelve), gated behind ability points and mutagens rather than just levels. Add the Grandmaster tiers of every Witcher set, the Manticore set, and the legendary silver sword Aerondight, and this is the best-equipped Geralt ever gets.